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-Structure paper
タイトル | 2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania. |
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ジャーナル・号・ページ | Cell Rep, Vol. 16, Issue 2, Page 288-294, Year 2016 |
掲載日 | 2016年7月12日 |
著者 | Moran Shalev-Benami / Yan Zhang / Donna Matzov / Yehuda Halfon / Arie Zackay / Haim Rozenberg / Ella Zimmerman / Anat Bashan / Charles L Jaffe / Ada Yonath / Georgios Skiniotis / |
PubMed 要旨 | Leishmania is a single-cell eukaryotic parasite of the Trypanosomatidae family, whose members cause an array of tropical diseases. The often fatal outcome of infections, lack of effective vaccines, ...Leishmania is a single-cell eukaryotic parasite of the Trypanosomatidae family, whose members cause an array of tropical diseases. The often fatal outcome of infections, lack of effective vaccines, limited selection of therapeutic drugs, and emerging resistant strains, underline the need to develop strategies to combat these pathogens. The Trypanosomatid ribosome has recently been highlighted as a promising therapeutic target due to structural features that are distinct from other eukaryotes. Here, we present the 2.8-Å resolution structure of the Leishmania donovani large ribosomal subunit (LSU) derived from a cryo-EM map, further enabling the structural observation of eukaryotic rRNA modifications that play a significant role in ribosome assembly and function. The structure illustrates the unique fragmented nature of leishmanial LSU rRNA and highlights the irregular distribution of rRNA modifications in Leishmania, a characteristic with implications for anti-parasitic drug development. |
リンク | Cell Rep / PubMed:27373148 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 2.8 Å |
構造データ | |
化合物 | ChemComp-MG: ChemComp-HOH: |
由来 |
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キーワード | RIBOSOME / Leishmania donovani / the large ribosomal subunit / eukaryotic parasite |