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-Structure paper
| Title | Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. |
|---|---|
| Journal, issue, pages | Nature, Vol. 535, Page 148-152, Year 2016 |
| Publish date | Oct 28, 2015 (structure data deposition date) |
 Authors | Chen, Y.P. / LaMarche, M.J. / Chan, H.M. / Fekkes, P. / Garcia-Fortanet, J. / Acker, M.G. / Antonakos, B. / Chen, C.H. / Chen, Z. / Cooke, V.G. ...Chen, Y.P. / LaMarche, M.J. / Chan, H.M. / Fekkes, P. / Garcia-Fortanet, J. / Acker, M.G. / Antonakos, B. / Chen, C.H. / Chen, Z. / Cooke, V.G. / Dobson, J.R. / Deng, Z. / Fei, F. / Firestone, B. / Fodor, M. / Fridrich, C. / Gao, H. / Grunenfelder, D. / Hao, H.X. / Jacob, J. / Ho, S. / Hsiao, K. / Kang, Z.B. / Karki, R. / Kato, M. / Larrow, J. / La Bonte, L.R. / Lenoir, F. / Liu, G. / Liu, S. / Majumdar, D. / Meyer, M.J. / Palermo, M. / Perez, L. / Pu, M. / Price, E. / Quinn, C. / Shakya, S. / Shultz, M.D. / Slisz, J. / Venkatesan, K. / Wang, P. / Warmuth, M. / Williams, S. / Yang, G. / Yuan, J. / Zhang, J.H. / Zhu, P. / Ramsey, T. / Keen, N.J. / Sellers, W.R. / Stams, T. / Fortin, P.D. |
 External links | Nature / PubMed:27362227 |
| Methods | X-ray diffraction |
| Resolution | 1.7 Å |
| Structure data |  PDB-5ehr: |
| Chemicals |  ChemComp-5OD:  ChemComp-PO4:  ChemComp-HOH: |
| Source |
|
 Keywords | Hydrolase/Hydrolase Inhibitor / Phosphatase PTP Inhibitor PTPN11 Allosteric / Hydrolase-Hydrolase Inhibitor complex |
homo sapiens (human)