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TitleHIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant.
Journal, issue, pagesCell, Vol. 166, Issue 1, Page 77-87, Year 2016
Publish dateJun 30, 2016
AuthorsCassandra A Simonich / Katherine L Williams / Hans P Verkerke / James A Williams / Ruth Nduati / Kelly K Lee / Julie Overbaugh /
PubMed AbstractHIV-1 broadly neutralizing antibodies (bnAbs) develop in a subset of infected adults and exhibit high levels of somatic hypermutation (SHM) due to years of affinity maturation. There is no precedent ...HIV-1 broadly neutralizing antibodies (bnAbs) develop in a subset of infected adults and exhibit high levels of somatic hypermutation (SHM) due to years of affinity maturation. There is no precedent for eliciting highly mutated antibodies by vaccination, nor is it practical to wait years for a desired response. Infants develop broad responses early, which may suggest a more direct path to generating bnAbs. Here, we isolated ten neutralizing antibodies (nAbs) contributing to plasma breadth of an infant at ∼1 year post-infection, including one with cross-clade breadth. The nAbs bind to envelope trimer from the transmitted virus, suggesting that this interaction may have initiated development of the infant nAbs. The infant cross-clade bnAb targets the N332 supersite on envelope but, unlike adult bnAbs targeting this site, lacks indels and has low SHM. The identification of this infant bnAb illustrates that HIV-1-specific neutralization breadth can develop without prolonged affinity maturation and extensive SHM.
External linksCell / PubMed:27345369 / PubMed Central
MethodsEM (single particle)
Resolution10.9 Å
Structure data

EMDB-8168:
BF520.1 Fab fragment bound to BG505 T332N SOSIP.664 trimer
Method: EM (single particle) / Resolution: 10.9 Å

Source
  • Homo sapiens (human)
  • Human immunodeficiency virus 1

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