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Title2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 7, Page 573-578, Year 2016
Publish dateFeb 15, 2016 (structure data deposition date)
AuthorsMallinger, A. / Schiemann, K. / Rink, C. / Sejberg, J. / Honey, M.A. / Czodrowski, P. / Stubbs, M. / Poeschke, O. / Busch, M. / Schneider, R. ...Mallinger, A. / Schiemann, K. / Rink, C. / Sejberg, J. / Honey, M.A. / Czodrowski, P. / Stubbs, M. / Poeschke, O. / Busch, M. / Schneider, R. / Schwarz, D. / Musil, D. / Burke, R. / Urbahns, K. / Workman, P. / Wienke, D. / Clarke, P.A. / Raynaud, F.I. / Eccles, S.A. / Esdar, C. / Rohdich, F. / Blagg, J.
External linksAcs Med. Chem. Lett. / PubMed:27326329
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-5i5z:
CDK8-CYCC IN COMPLEX WITH 8-(1-Methyl-2,2-dioxo-2,3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-[1,6]naphthyridine-2-carboxylic acid methylamide
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-68U:
N-methyl-8-(1-methyl-2,2-dioxo-2,3-dihydro-1H-2lambda~6~,1-benzothiazol-5-yl)-1,6-naphthyridine-2-carboxamide

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CDK8 KINASE / CYCLIN C

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