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Structure paper

TitleElucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
Journal, issue, pagesJ. Thromb. Haemost., Vol. 14, Page 1629-1638, Year 2016
Publish dateJan 28, 2016 (structure data deposition date)
AuthorsZhou, X. / Weeks, S.D. / Ameloot, P. / Callewaert, N. / Strelkov, S.V. / Declerck, P.J.
External linksJ. Thromb. Haemost. / PubMed:27279497
MethodsX-ray diffraction
Resolution2.85 - 3.05 Å
Structure data

PDB-5hvf:
Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83)
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

PDB-5hvg:
Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204)
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

PDB-5hvh:
Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ZN:
Unknown entry

ChemComp-FLC:
CITRATE ANION

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
  • vicugna pacos (alpaca)
Keywordshydrolase/hydrolase inhibitor / procarboxypeptidase U / thrombin-activatable fibrinolysis inhibitor / TAFI / procarboxypeptidase R / plasma procarboxypeptidase B / nanobody / antibody fragment / protein complex / HYDROLASE / hydrolase-hydrolase inhibitor complex

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