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Structure paper

TitleStructural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.
Journal, issue, pagesJ. Struct. Biol., Vol. 195, Page 199-206, Year 2016
Publish dateMar 2, 2016 (structure data deposition date)
AuthorsHausmann, J. / Keune, W.J. / Hipgrave Ederveen, A.L. / van Zeijl, L. / Joosten, R.P. / Perrakis, A.
External linksJ. Struct. Biol. / PubMed:27268273
MethodsX-ray diffraction
Resolution2.05 - 2.2 Å
Structure data

PDB-5ijq:
Crystal structure of autotaxin (ENPP2) re-refined
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-5ijs:
Crystal structure of autotaxin with orthovanadate bound as a trigonal bipyramidal intermediate analog
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-5JK:
7alpha-hydroxycholesterol

ChemComp-SCN:
THIOCYANATE ION

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-CA:
Unknown entry

ChemComp-IOD:
IODIDE ION

ChemComp-NA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsHYDROLASE / LYSOPHOSPHATIDYLCHOLINE / SOMATOMEDIN / INFLAMMATION / METASTASIS / NEUROPATHIC PAIN / VASCULAR DEVELOPMENT / NEURAL DEVELOPMENT

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