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Structure paper

TitleMechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5 alpha.
Journal, issue, pagesElife, Vol. 5, Year 2016
Publish dateOct 30, 2015 (structure data deposition date)
AuthorsWagner, J.M. / Roganowicz, M.D. / Skorupka, K. / Alam, S.L. / Christensen, D.E. / Doss, G.L. / Wan, Y. / Frank, G.A. / Ganser-Pornillos, B.K. / Sundquist, W.I. / Pornillos, O.
External linksElife / PubMed:27253059
MethodsX-ray diffraction
Resolution1.908 - 3.258 Å
Structure data

PDB-5eiu:
Mini TRIM5 B-box 2 dimer C2 crystal form
Method: X-RAY DIFFRACTION / Resolution: 1.908 Å

PDB-5f7t:
TRIM5 B-box2 and coiled-coil chimera
Method: X-RAY DIFFRACTION / Resolution: 2.292 Å

PDB-5iea:
TRIM5 B-box2 and coiled-coil chimera
Method: X-RAY DIFFRACTION / Resolution: 3.258 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • macaca mulatta (Rhesus monkey)
  • thermus thermophilus (strain hb27 / atcc baa-163 / dsm 7039) (bacteria)
KeywordsLIGASE / tripartite motif / HIV / viral restriction / TRIM protein / E3 ligase / self-assembly / pattern recognition / TRIM

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