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Structure paper

TitleStructure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.
Journal, issue, pagesJ. Mol. Biol., Vol. 428, Page 2769-2779, Year 2016
Publish dateMar 23, 2016 (structure data deposition date)
AuthorsWang, H. / Klein, M.G. / Snell, G. / Lane, W. / Zou, H. / Levin, I. / Li, K. / Sang, B.C.
External linksJ. Mol. Biol. / PubMed:27220631
MethodsX-ray diffraction
Resolution2.2 - 3.25 Å
Structure data

PDB-5ixc:
Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-5iz5:
Human GIVD cytosolic phospholipase A2
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-5izr:
Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate inhibitor and Terbium Chloride
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

Chemicals

ChemComp-7FA:
methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate

ChemComp-BA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-TB:
TERBIUM(III) ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE inhibitor / Inhibitor / Signal Transduction / Phospholipase / alpha/beta hydrolase / Calcium binding / C2 domain / HYDROLASE / HYDROLASE-HYDROLASE inhibitor complex

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