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Structure paper

TitleThe Discovery and Characterization of K-756, a Novel Wnt/ beta-Catenin Pathway Inhibitor Targeting Tankyrase
Journal, issue, pagesMol. Cancer Ther., Vol. 15, Page 1525-1534, Year 2016
Publish dateNov 18, 2015 (structure data deposition date)
AuthorsOkada-Iwasaki, R. / Takahashi, Y. / Watanabe, Y. / Ishida, H. / Saito, J. / Nakai, R. / Asai, A.
External linksMol. Cancer Ther. / PubMed:27196752
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-5ety:
Crystal Structure of human Tankyrase-1 bound to K-756
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-K56:
3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-1,4-dihydroquinazolin-2-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Tankyrase / inhibitor / non-competitive / Wnt signal

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