タイトル | Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. |
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ジャーナル・号・ページ | Sci Rep, Vol. 6, Page 26213-26213, Year 2016 |
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掲載日 | 2015年4月20日 (構造データの登録日) |
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著者 | Sagatova, A.A. / Keniya, M.V. / Wilson, R.K. / Sabherwal, M. / Tyndall, J.D. / Monk, B.C. |
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リンク | Sci Rep / PubMed:27188873 |
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手法 | X線回折 |
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解像度 | 2.02 - 2.3 Å |
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構造データ | PDB-4zdy: Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with itraconazole 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-4zdz: Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with fluconazole 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-4ze0: Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with Voriconazole 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4ze1: Saccharomyces cerevisiae CYP51 Y140F mutant complexed with posaconazole in the active site 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4ze2: Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with itraconazole 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-4ze3: Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with fluconazole 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5hs1: Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) complexed with Voriconazole 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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化合物 | ChemComp-1YN: 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one / 4-[4-[4-[4-[[(2R,4S)-2-(2,4-ジクロロフェニル)-2-[(1H-1,2,4-トリアゾ-ル-1(以下略) / 薬剤, 抗真菌剤*YM
ChemComp-TPF: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL / フルコナゾ-ル / 薬剤, 抗真菌剤*YM
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由来 | - saccharomyces cerevisiae (strain yjm789) (パン酵母)
- saccharomyces cerevisiae (パン酵母)
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キーワード | oxidoreductase/oxidoreductase inhibitor / Itraconazole / CYP51 / oxidoreductase-oxidoreducatse inhibitor complex / resistance mutation / oxidoreductase-oxidoreductase inhibitor complex / oxidoreductase/oxidoreducatse inhibitor / Y140F / Fluconazole / Y140H / Voriconazole |
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