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Title | Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 4711-4723, Year 2016 |
Publish date | Feb 29, 2016 (structure data deposition date) |
![]() | Toure, B.B. / Giraldes, J. / Smith, T. / Sprague, E.R. / Wang, Y. / Mathieu, S. / Chen, Z. / Mishina, Y. / Feng, Y. / Yan-Neale, Y. ...Toure, B.B. / Giraldes, J. / Smith, T. / Sprague, E.R. / Wang, Y. / Mathieu, S. / Chen, Z. / Mishina, Y. / Feng, Y. / Yan-Neale, Y. / Shakya, S. / Chen, D. / Meyer, M. / Puleo, D. / Brazell, J.T. / Straub, C. / Sage, D. / Wright, K. / Yuan, Y. / Chen, X. / Duca, J. / Kim, S. / Tian, L. / Martin, E. / Hurov, K. / Shao, W. |
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Methods | X-ray diffraction |
Resolution | 1.79 - 2.14 Å |
Structure data | ![]() PDB-5ih8: ![]() PDB-5ih9: ![]() PDB-5iha: ![]() PDB-5ihc: |
Chemicals | ![]() ChemComp-6BJ: ![]() ChemComp-HOH: ![]() ChemComp-6BF: ![]() ChemComp-6BE: ![]() ChemComp-6BB: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / kinase UBA domain inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |