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TitleA natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer.
Journal, issue, pagesOncotarget, Vol. 7, Page 35001-35014, Year 2016
Publish dateMay 20, 2015 (structure data deposition date)
AuthorsLim do, Y. / Shin, S.H. / Lee, M.H. / Malakhova, M. / Kurinov, I. / Wu, Q. / Xu, J. / Jiang, Y. / Dong, Z. / Liu, K. ...Lim do, Y. / Shin, S.H. / Lee, M.H. / Malakhova, M. / Kurinov, I. / Wu, Q. / Xu, J. / Jiang, Y. / Dong, Z. / Liu, K. / Lee, K.Y. / Bae, K.B. / Choi, B.Y. / Deng, Y. / Bode, A.
External linksOncotarget / PubMed:27167001
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4zxt:
Complex of ERK2 with catechol
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-CAQ:
CATECHOL

ChemComp-SO4:
SULFATE ION

ChemComp-NH4:
AMMONIUM ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / catechol complex / mitogen-activated protein kinase / signal-regulated kinase

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