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TitleCharacterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
Journal, issue, pagesOncogene, Vol. 35, Page 6077-6086, Year 2016
Publish dateAug 1, 2015 (structure data deposition date)
AuthorsBernasconi-Elias, P. / Hu, T. / Jenkins, D. / Firestone, B. / Gans, S. / Kurth, E. / Capodieci, P. / Deplazes-Lauber, J. / Petropoulos, K. / Thiel, P. ...Bernasconi-Elias, P. / Hu, T. / Jenkins, D. / Firestone, B. / Gans, S. / Kurth, E. / Capodieci, P. / Deplazes-Lauber, J. / Petropoulos, K. / Thiel, P. / Ponsel, D. / Hee Choi, S. / LeMotte, P. / London, A. / Goetcshkes, M. / Nolin, E. / Jones, M.D. / Slocum, K. / Kluk, M.J. / Weinstock, D.M. / Christodoulou, A. / Weinberg, O. / Jaehrling, J. / Ettenberg, S.A. / Buckler, A. / Blacklow, S.C. / Aster, J.C. / Fryer, C.J.
External linksOncogene / PubMed:27157619
MethodsX-ray diffraction
Resolution2.1 - 3.19 Å
Structure data

PDB-5czv:
Crystal structure of Notch3 NRR in complex with 20350 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.19 Å

PDB-5czx:
Crystal structure of Notch3 NRR in complex with 20358 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ANTIBODY / NOTCH3 / ONCOLOGY

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