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TitleEngineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.
Journal, issue, pagesJ. Biol. Chem., Vol. 291, Page 13974-13986, Year 2016
Publish dateNov 11, 2015 (structure data deposition date)
AuthorsShcherbatko, A. / Rossi, A. / Foletti, D. / Zhu, G. / Bogin, O. / Galindo Casas, M. / Rickert, M. / Hasa-Moreno, A. / Bartsevich, V. / Crameri, A. ...Shcherbatko, A. / Rossi, A. / Foletti, D. / Zhu, G. / Bogin, O. / Galindo Casas, M. / Rickert, M. / Hasa-Moreno, A. / Bartsevich, V. / Crameri, A. / Steiner, A.R. / Henningsen, R. / Gill, A. / Pons, J. / Shelton, D.L. / Rajpal, A. / Strop, P.
External linksJ. Biol. Chem. / PubMed:27129258
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-5epm:
Ceratotoxin variant in complex with specific antibody Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • ceratogyrus marshalli (spider)
KeywordsTOXIN/IMMUNE SYSTEM / Ceratotoxin / random mutagenesis / Nav1.7 ion chanel / TOXIN-IMMUNE SYSTEM complex

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