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TitleStructural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Journal, issue, pagesNat Commun, Vol. 7, Page 11316-11316, Year 2016
Publish dateFeb 1, 2016 (structure data deposition date)
AuthorsJustin, N. / Zhang, Y. / Tarricone, C. / Martin, S.R. / Chen, S. / Underwood, E. / De Marco, V. / Haire, L.F. / Walker, P.A. / Reinberg, D. ...Justin, N. / Zhang, Y. / Tarricone, C. / Martin, S.R. / Chen, S. / Underwood, E. / De Marco, V. / Haire, L.F. / Walker, P.A. / Reinberg, D. / Wilson, J.R. / Gamblin, S.J.
External linksNat Commun / PubMed:27121947
MethodsX-ray diffraction
Resolution2.95 Å
Structure data

PDB-5hyn:
Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / chromatin modification complex

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