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-Structure paper
Title | Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. |
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Journal, issue, pages | Acs Chem. Biol., Vol. 11, Page 1710-1719, Year 2016 |
Publish date | Feb 25, 2016 (structure data deposition date) |
![]() | Ayaz, P. / Andres, D. / Kwiatkowski, D.A. / Kolbe, C.C. / Lienau, P. / Siemeister, G. / Luecking, U. / Stegmann, C.M. |
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Methods | X-ray diffraction |
Resolution | 1.66 - 2.61 Å |
Structure data | ![]() PDB-5iev: ![]() PDB-5iex: ![]() PDB-5iey: ![]() PDB-5if1: |
Chemicals | ![]() ChemComp-R0N: ![]() ChemComp-HOH: ![]() ChemComp-6AF: ![]() ChemComp-6AE: |
Source |
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![]() | TRANSFERASE / Antineoplastic Agents / Cyclin-Dependent Kinases / Dose-Response Relationship / Drug / Drug Discovery / HeLa Cells / Neoplasms / Protein Kinase Inhibitors / Pyrimidines / Structure-Activity Relationship / Structure-Kinetics Relationship / Sulfoxides / Biophysical Assays / Tumor / Molecular Structure / Humans |