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TitleRibosome Biogenesis Factor Tsr3 is the Aminocarboxypropyl Transferase Responsible for 18S Rrna Hypermodification in Yeast and Humans
Journal, issue, pagesNucleic Acids Res., Vol. 44, Page 4304-, Year 2016
Publish dateSep 14, 2015 (structure data deposition date)
AuthorsEntian, K.-D. / Immer, C. / Koetter, P. / Lafontaine, D. / Britter, M. / Pogoryelov, D. / Sharma, S. / Wohnert, J. / Wurm, J.P.
External linksNucleic Acids Res. / PubMed:27084949
MethodsX-ray diffraction
Resolution1.6 - 2.246 Å
Structure data

PDB-5ap8:
Structure of the SAM-dependent rRNA:acp-transferase Tsr3 from S. solfataricus
Method: X-RAY DIFFRACTION / Resolution: 2.246 Å

PDB-5apg:
Structure of the SAM-dependent rRNA:acp-transferase Tsr3 from Vulcanisaeta distributa
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-EEM:
[(3S)-3-amino-4-hydroxy-4-oxo-butyl]-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl]-methyl-selanium

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • sulfolobus solfataricus (archaea)
  • vulcanisaeta distributa (archaea)
KeywordsTRANSFERASE / S-ADENOSYLMETHIONINE DEPENDENT 3-AMINO-3-CARBOXYPROPYL TRANSFERASE / RRNA / PSEUDOURIDINE / SAM / SPOUT-FOLD / S-ADENOSYLMETHIONINE

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