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Structure paper

TitleControl of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.
Journal, issue, pagesScience, Vol. 352, Page 986-990, Year 2016
Publish dateMar 1, 2016 (structure data deposition date)
AuthorsWild, R. / Gerasimaite, R. / Jung, J.Y. / Truffault, V. / Pavlovic, I. / Schmidt, A. / Saiardi, A. / Jessen, H.J. / Poirier, Y. / Hothorn, M. / Mayer, A.
External linksScience / PubMed:27080106
MethodsX-ray diffraction
Resolution1.95 - 3.03 Å
Structure data

PDB-5iig:
Structure of the SPX-TTM domain fragment of the yeast inorganic polyphophate polymerase Vtc4 (form A).
Method: X-RAY DIFFRACTION / Resolution: 2.99 Å

PDB-5iiq:
Structure of the SPX-TTM domain fragment of the yeast inorganic polyphophate polymerase Vtc4 (form B).
Method: X-RAY DIFFRACTION / Resolution: 3.03 Å

PDB-5iit:
Structure of SPX domain of the yeast inorganic polyphophate polymerase Vtc4 crystallized by carrier-driven crystallization in fusion with the macro domain of human histone macroH2A1.1
Method: X-RAY DIFFRACTION / Resolution: 2.134 Å

PDB-5ijh:
Structure of the SPX domain of the human phosphate transporter XPR1 in complex with a sulfate ion
Method: X-RAY DIFFRACTION / Resolution: 2.43 Å

PDB-5ijj:
Structure of the SPX domain of Chaetomium thermophilum Glycerophosphodiester Phosphodiesterase 1 in complex with inositol hexakisphosphate (InsP6)
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-5ijp:
Crystal structure of the SPX domain of Chaetomium thermophilum Vtc4 in complex with inositol hexakisphosphate (InsP6).
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-SO4:
SULFATE ION / Sulfate

ChemComp-POP:
PYROPHOSPHATE 2- / Pyrophosphate

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM / MES (buffer)

ChemComp-EDO:
1,2-ETHANEDIOL / Ethylene glycol

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER / Water

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE / Phytic acid

ChemComp-ACT:
ACETATE ION / Acetate

Source
  • saccharomyces cerevisiae (brewer's yeast)
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
  • homo sapiens (human)
  • chaetomium thermophilum (fungus)
KeywordsTRANSFERASE / helical bundle / alpha-helical hairpin / inositol phosphate binding / protein-protein interaction / chaperone / inositol phosphate binding protein / Signaling protein / inositol polyphosphate binding protein / Hydrolase / structural protein

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