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Title | Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 24, Page 2257-2272, Year 2016 |
Publish date | Nov 23, 2015 (structure data deposition date) |
![]() | Corte, J.R. / Fang, T. / Pinto, D.J.P. / Orwat, M.J. / Han, W. / Rendina, A.R. / Luettgen, J.M. / Rossi, K.A. / Wei, A. / Ramamurthy, V. ...Corte, J.R. / Fang, T. / Pinto, D.J.P. / Orwat, M.J. / Han, W. / Rendina, A.R. / Luettgen, J.M. / Rossi, K.A. / Wei, A. / Ramamurthy, V. / Myers Jr., J.E. / Sheriff, S. / Narayanan, R. / Harper, T. / Zheng, J.J. / Li, Y.-X. / Seiffert, D.A. / Wexler, R.R. / Quan, M.L. |
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Methods | X-ray diffraction |
Resolution | 1.49 - 2.3 Å |
Structure data | ![]() PDB-5exl: ![]() PDB-5exm: ![]() PDB-5exn: |
Chemicals | ![]() ChemComp-5SS: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-5ST: ![]() ChemComp-NAG: ![]() ChemComp-5SU: |
Source |
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![]() | HYDROLASE/HYDROLASE Inhibitor / HYDROLASE / SERINE PROTEASE / BLOOD COAGULATION FACTOR / PROTEIN INHIBITOR COMPLEX / HYDROLASE-HYDROLASE Inhibitor complex / COAGULATION FACTOR / SYNTETHIC INHIBITOR / BLOOD |