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Structure paper

TitleUncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 alpha C helix.
Journal, issue, pagesBiochem. J., Vol. 473, Page 1579-1591, Year 2016
Publish dateFeb 12, 2016 (structure data deposition date)
AuthorsLeroy, E. / Dusa, A. / Colau, D. / Motamedi, A. / Cahu, X. / Mouton, C. / Huang, L.J. / Shiau, A.K. / Constantinescu, S.N.
External linksBiochem. J. / PubMed:27029346
MethodsX-ray diffraction
Resolution1.54 Å
Structure data

PDB-5i4n:
Crystal Structure of the E596A V617F Mutant JAK2 Pseudokinase Domain Bound to Mg-ATP
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PSEUDOKINASE / ATP BINDING

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