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TitleProtease-resistant modified human beta-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
Journal, issue, pagesJ. Clin. Invest., Vol. 126, Page 1691-1703, Year 2016
Publish dateJun 1, 2015 (structure data deposition date)
AuthorsKitakaze, K. / Mizutani, Y. / Sugiyama, E. / Tasaki, C. / Tsuji, D. / Maita, N. / Hirokawa, T. / Asanuma, D. / Kamiya, M. / Sato, K. ...Kitakaze, K. / Mizutani, Y. / Sugiyama, E. / Tasaki, C. / Tsuji, D. / Maita, N. / Hirokawa, T. / Asanuma, D. / Kamiya, M. / Sato, K. / Setou, M. / Urano, Y. / Togawa, T. / Otaka, A. / Sakuraba, H. / Itoh, K.
External linksJ. Clin. Invest. / PubMed:27018595
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-5bro:
Crystal structure of modified HexB (modB)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Therapeutic enzyme

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