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Structure paper

TitleA novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Journal, issue, pagesBlood, Vol. 127, Page 2915-2923, Year 2016
Publish dateNov 10, 2015 (structure data deposition date)
AuthorsWong, S.S. / stergaard, S. / Hall, G. / Li, C. / Williams, P.M. / Stennicke, H. / Emsley, J.
External linksBlood / PubMed:27006387
MethodsX-ray diffraction
Resolution2.8 - 3.1 Å
Structure data

PDB-5eod:
Human Plasma Coagulation FXI with peptide LP2
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-5eok:
Human Plasma Coagulation Factor XI in complex with peptide P39
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-5i25:
human recombinant coagulation FXI in complex with a peptide derived from human high molecular weight kininogen (HKP)
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / Human / plasma / Coagulation Factor XI / complex / Coagulation FXI / high molecular weight kininogen

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