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-Structure paper
Title | Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (Alk), C-Ros Oncogene 1 Kinase (Ros1), and Pan-Tropomyosin Receptor Kinases (Pan-Trks) Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 3392-, Year 2016 |
Publish date | Jan 14, 2016 (structure data deposition date) |
Authors | Menichincheri, M. / Ardini, E. / Magnaghi, P. / Avanzi, N. / Banfi, P. / Bossi, R.T. / Buffa, L. / Canevari, G. / Ceriani, L. / Colombo, M. ...Menichincheri, M. / Ardini, E. / Magnaghi, P. / Avanzi, N. / Banfi, P. / Bossi, R.T. / Buffa, L. / Canevari, G. / Ceriani, L. / Colombo, M. / Corti, L. / Donati, D. / Fasolini, M. / Felder, E.R. / Fiorelli, C. / Fiorentini, F. / Galvani, A. / Isacchi, A. / Borgia, A.L. / Marchionni, C. / Nesi, M. / Orrenius, C. / Panzeri, A. / Pesenti, E. / Rusconi, L. / Saccardo, B.M. / Vanotti, E. / Perrone, E. / Orsini, P. |
External links | J. Med. Chem. / PubMed:27003761 |
Methods | X-ray diffraction |
Resolution | 1.7 - 2.22 Å |
Structure data | PDB-5fto: PDB-5ftq: |
Chemicals | ChemComp-YMX: ChemComp-HOH: ChemComp-U4W: ChemComp-GOL: |
Source |
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Keywords | TRANSFERASE / KINASE INHIBITORS / CANCER / DRUG DISCOVERY / ALK / TRK / ROS1 / ANAPLASTIC LARGE CELL LYMPHOMA (ALCL) / NON SMALL CELL LARGE CANCER (NSCLC) / NEUROBLASTOMA / COLORECTAL CANCER (CRC) |