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TitleDevelopment of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 7, Page 223-228, Year 2016
Publish dateJul 6, 2015 (structure data deposition date)
AuthorsKoehler, M.F. / Bergeron, P. / Blackwood, E.M. / Bowman, K. / Clark, K.R. / Firestein, R. / Kiefer, J.R. / Maskos, K. / McCleland, M.L. / Orren, L. ...Koehler, M.F. / Bergeron, P. / Blackwood, E.M. / Bowman, K. / Clark, K.R. / Firestein, R. / Kiefer, J.R. / Maskos, K. / McCleland, M.L. / Orren, L. / Salphati, L. / Schmidt, S. / Schneider, E.V. / Wu, J. / Beresini, M.H.
External linksAcs Med. Chem. Lett. / PubMed:26985305
MethodsX-ray diffraction
Resolution2.24 Å
Structure data

PDB-5cei:
Crystal structure of CDK8:Cyclin C complex with compound 22
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-FMT:
FORMIC ACID

ChemComp-50R:
4-(4-iodophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTranscription/Transferase/Inhibitor / kinase / inhibitor / CDK8 / cyclin dependent kinase / cyclin / Transcription-Transferase-Inhibitor complex

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