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-Structure paper
| Title | Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis. |
|---|---|
| Journal, issue, pages | Acs Med. Chem. Lett., Vol. 7, Page 198-203, Year 2016 |
| Publish date | Dec 14, 2015 (structure data deposition date) |
 Authors | Liu, J. / Guiadeen, D. / Krikorian, A. / Gao, X. / Wang, J. / Boga, S.B. / Alhassan, A.B. / Yu, Y. / Vaccaro, H. / Liu, S. ...Liu, J. / Guiadeen, D. / Krikorian, A. / Gao, X. / Wang, J. / Boga, S.B. / Alhassan, A.B. / Yu, Y. / Vaccaro, H. / Liu, S. / Yang, C. / Wu, H. / Cooper, A. / de Man, J. / Kaptein, A. / Maloney, K. / Hornak, V. / Gao, Y.D. / Fischmann, T.O. / Raaijmakers, H. / Vu-Pham, D. / Presland, J. / Mansueto, M. / Xu, Z. / Leccese, E. / Zhang-Hoover, J. / Knemeyer, I. / Garlisi, C.G. / Bays, N. / Stivers, P. / Brandish, P.E. / Hicks, A. / Kim, R. / Kozlowski, J.A. |
 External links | Acs Med. Chem. Lett. / PubMed:26985298 |
| Methods | X-ray diffraction |
| Resolution | 1.8 - 1.894 Å |
| Structure data |  PDB-5fbn:  PDB-5fbo: |
| Chemicals |  ChemComp-5WF:  ChemComp-5WE:  ChemComp-CL:  ChemComp-EDO:  ChemComp-HOH:  ChemComp-5WH: |
| Source |
|
 Keywords | TRANSFERASE / KINASE / PHOSPHATASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX / TRANSFERASE/TRANSFERASE inhibitor |
homo sapiens (human)