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Structure paper

TitleCODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.
Journal, issue, pagesMabs, Vol. 8, Page 867-878, Year 2016
Publish dateDec 22, 2015 (structure data deposition date)
AuthorsSteinmetz, A. / Vallee, F. / Beil, C. / Lange, C. / Baurin, N. / Beninga, J. / Capdevila, C. / Corvey, C. / Dupuy, A. / Ferrari, P. ...Steinmetz, A. / Vallee, F. / Beil, C. / Lange, C. / Baurin, N. / Beninga, J. / Capdevila, C. / Corvey, C. / Dupuy, A. / Ferrari, P. / Rak, A. / Wonerow, P. / Kruip, J. / Mikol, V. / Rao, E.
External linksMabs / PubMed:26984268
MethodsX-ray diffraction
Resolution2.55 - 2.68 Å
Structure data

PDB-5fhx:
CRYSTAL STRUCTURE OF CODV IN COMPLEX WITH IL4 AT 2.55 Ang. RESOLUTION.
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-5hcg:
CRYSTAL STRUCTURE OF FREE-CODV.
Method: X-RAY DIFFRACTION / Resolution: 2.68 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / cross-over dual variable immunoglobulin multifunctional biotherapeutic drug / CODV / cross-over dual variable immunoglobin / multifunctional biotherapeutic format / bispecific property

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