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TitleInhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page 3527-3532, Year 2016
Publish dateFeb 22, 2016 (structure data deposition date)
AuthorsGorelik, M. / Orlicky, S. / Sartori, M.A. / Tang, X. / Marcon, E. / Kurinov, I. / Greenblatt, J.F. / Tyers, M. / Moffat, J. / Sicheri, F. / Sidhu, S.S.
External linksProc. Natl. Acad. Sci. USA / PubMed:26976582
MethodsX-ray diffraction
Resolution2.503 Å
Structure data

PDB-5ibk:
Skp1-F-box in complex with a ubiquitin variant
Method: X-RAY DIFFRACTION / Resolution: 2.503 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / phage display / SCF inhibitors / Fbxw7 / Fbxw11 / ?-Trcp / ubiquitin

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