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-Structure paper
Title | N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity. |
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Journal, issue, pages | Chemmedchem, Vol. 11, Page 687-701, Year 2016 |
Publish date | Jul 21, 2014 (structure data deposition date) |
![]() | Guardia, A. / Gulten, G. / Fernandez, R. / Gomez, J. / Wang, F. / Convery, M. / Blanco, D. / Martinez, M. / Perez-Herran, E. / Alonso, M. ...Guardia, A. / Gulten, G. / Fernandez, R. / Gomez, J. / Wang, F. / Convery, M. / Blanco, D. / Martinez, M. / Perez-Herran, E. / Alonso, M. / Ortega, F. / Rullas, J. / Calvo, D. / Mata, L. / Young, R. / Sacchettini, J.C. / Mendoza-Losana, A. / Remuinan, M. / Ballell Pages, L. / Castro-Pichel, J. |
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Methods | X-ray diffraction |
Resolution | 2.196 Å |
Structure data | ![]() PDB-4qxm: |
Chemicals | ![]() ChemComp-NAD: ![]() ChemComp-713: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Rossman fold / enoyl-ACP reductase / NADH binding / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |