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Structure paper

TitleAutoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page 3012-3017, Year 2016
Publish dateJan 5, 2016 (structure data deposition date)
AuthorsTanji, H. / Ohto, U. / Motoi, Y. / Shibata, T. / Miyake, K. / Shimizu, T.
External linksProc. Natl. Acad. Sci. USA / PubMed:26929371
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-5hdh:
Crystal structure of human TLR8 with an uncleaved Z-loop
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / TLR8 / innate immunity / proteolytic cleavage

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