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TitleCholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page E1266-E1275, Year 2016
Publish dateJun 27, 2015 (structure data deposition date)
AuthorsMansour, S. / Tocheva, A.S. / Cave-Ayland, C. / Machelett, M.M. / Sander, B. / Lissin, N.M. / Molloy, P.E. / Baird, M.S. / Stubs, G. / Schroder, N.W. ...Mansour, S. / Tocheva, A.S. / Cave-Ayland, C. / Machelett, M.M. / Sander, B. / Lissin, N.M. / Molloy, P.E. / Baird, M.S. / Stubs, G. / Schroder, N.W. / Schumann, R.R. / Rademann, J. / Postle, A.D. / Jakobsen, B.K. / Marshall, B.G. / Gosain, R. / Elkington, P.T. / Elliott, T. / Skylaris, C.K. / Essex, J.W. / Tews, I. / Gadola, S.D.
External linksProc. Natl. Acad. Sci. USA / PubMed:26884207
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-5c9j:
Human CD1c with ligands in A' and F' channel
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-DAO:
LAURIC ACID

ChemComp-STE:
STEARIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antigen Presentation / CD1 / human CD1 / MHC-like / Immunology / lipid antigen

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