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-Structure paper
Title | The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity. |
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Journal, issue, pages | Eur J Med Chem, Vol. 112, Page 20-32, Year 2016 |
Publish date | Mar 11, 2015 (structure data deposition date) |
![]() | Newton, R. / Bowler, K.A. / Burns, E.M. / Chapman, P.J. / Fairweather, E.E. / Fritzl, S.J.R. / Goldberg, K.M. / Hamilton, N.M. / Holt, S.V. / Hopkins, G.V. ...Newton, R. / Bowler, K.A. / Burns, E.M. / Chapman, P.J. / Fairweather, E.E. / Fritzl, S.J.R. / Goldberg, K.M. / Hamilton, N.M. / Holt, S.V. / Hopkins, G.V. / Jones, S.D. / Jordan, A.M. / Lyons, A.J. / Nikki March, H. / McDonald, N.Q. / Maguire, L.A. / Mould, D.P. / Purkiss, A.G. / Small, H.F. / Stowell, A.I.J. / Thomson, G.J. / Waddell, I.D. / Waszkowycz, B. / Watson, A.J. / Ogilvie, D.J. |
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Methods | X-ray diffraction |
Resolution | 2.57 Å |
Structure data | ![]() PDB-5amn: |
Chemicals | ![]() ChemComp-DTQ: ![]() ChemComp-FMT: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / RET / ONCOGENE / RECEPTOR TYROSINE KINASE / CHEMICAL INHIBITOR / CANCER |