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TitleStructure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution.
Journal, issue, pagesScience, Vol. 246, Page 1149-1152, Year 1989
Publish dateAug 8, 1989 (structure data deposition date)
AuthorsMiller, M. / Schneider, J. / Sathyanarayana, B.K. / Toth, M.V. / Marshall, G.R. / Clawson, L. / Selk, L. / Kent, S.B. / Wlodawer, A.
External linksPubMed:2686029
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4hvp:
Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Angstroms resolution
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-2NC:
N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE/HYDROLASE INHIBITOR / ACID PROTEINASE / HYDROLASE-HYDROLASE INHIBITOR complex

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