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Structure paper

TitleOvercoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma.
Journal, issue, pagesProtein Eng. Des. Sel., Vol. 29, Page 135-147, Year 2016
Publish dateAug 17, 2015 (structure data deposition date)
AuthorsGrossman, I. / Ilani, T. / Fleishman, S.J. / Fass, D.
External linksProtein Eng. Des. Sel. / PubMed:26819240
MethodsX-ray diffraction
Resolution2.05 - 2.3 Å
Structure data

PDB-5d8i:
Engineering the Species-Specificity of an Inhibitory Antibody Targeting a Modulator of Tumor Stroma
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-5d93:
Oxidoreductase Fragment of Mouse QSOX1 in Complex with a FAb Fragment from a Mouse QSOX1-Specific Antibody
Method: X-RAY DIFFRACTION / Resolution: 2.201 Å

PDB-5d96:
Oxidoreductase Fragment of Mouse QSOX1 in Complex with a FAb Fragment from an Antibody Targeting Mouse and Human QSOX1
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsOXIDOREDUCTASE / enzyme / disulfide bonds / thioredoxin fold / inhibitor / antibody / IMMUNE SYSTEM / dual-specificity

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