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-Structure paper
Title | Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 1078-1101, Year 2016 |
Publish date | Dec 20, 2015 (structure data deposition date) |
Authors | Mallinger, A. / Schiemann, K. / Rink, C. / Stieber, F. / Calderini, M. / Crumpler, S. / Stubbs, M. / Adeniji-Popoola, O. / Poeschke, O. / Busch, M. ...Mallinger, A. / Schiemann, K. / Rink, C. / Stieber, F. / Calderini, M. / Crumpler, S. / Stubbs, M. / Adeniji-Popoola, O. / Poeschke, O. / Busch, M. / Czodrowski, P. / Musil, D. / Schwarz, D. / Ortiz-Ruiz, M.J. / Schneider, R. / Thai, C. / Valenti, M. / de Haven Brandon, A. / Burke, R. / Workman, P. / Dale, T. / Wienke, D. / Clarke, P.A. / Esdar, C. / Raynaud, F.I. / Eccles, S.A. / Rohdich, F. / Blagg, J. |
External links | J. Med. Chem. / PubMed:26796641 |
Methods | X-ray diffraction |
Resolution | 2.36 - 3 Å |
Structure data | PDB-5fgk: PDB-5hbe: PDB-5hbh: PDB-5hbj: |
Chemicals | ChemComp-5XG: ChemComp-DMS: ChemComp-EDO: ChemComp-FMT: ChemComp-HOH: ChemComp-5Y6: ChemComp-5Y7: ChemComp-5Y8: |
Source |
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Keywords | TRANSFERASE / CDK8 KINASE / CYCLIN C |