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Title | Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives. |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 1370-1387, Year 2016 |
Publish date | Nov 27, 2015 (structure data deposition date) |
Authors | Westaway, S.M. / Preston, A.G. / Barker, M.D. / Brown, F. / Brown, J.A. / Campbell, M. / Chung, C.W. / Drewes, G. / Eagle, R. / Garton, N. ...Westaway, S.M. / Preston, A.G. / Barker, M.D. / Brown, F. / Brown, J.A. / Campbell, M. / Chung, C.W. / Drewes, G. / Eagle, R. / Garton, N. / Gordon, L. / Haslam, C. / Hayhow, T.G. / Humphreys, P.G. / Joberty, G. / Katso, R. / Kruidenier, L. / Leveridge, M. / Pemberton, M. / Rioja, I. / Seal, G.A. / Shipley, T. / Singh, O. / Suckling, C.J. / Taylor, J. / Thomas, P. / Wilson, D.M. / Lee, K. / Prinjha, R.K. |
External links | J. Med. Chem. / PubMed:26771203 |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-5fp7: |
Chemicals | ChemComp-ZN: ChemComp-FE2: ChemComp-GOL: ChemComp-YC8: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | INHIBITOR / LYSINE SPECIFIC HISTONE DEMETHYLASE / JMJD2D / KDM4D / JUMONJI |