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TitleDouble Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 54, Page 15410-, Year 2015
Publish dateJan 22, 2015 (structure data deposition date)
AuthorsLau, Y.H. / Wu, Y. / Rossmann, M. / Tan, B.X. / De Andrade, P. / Tan, Y.S. / Verma, C. / Mckenzie, G.J. / Venkitaraman, A.R. / Hyvonen, M. / Spring, D.R.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:26768531
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-5afg:
Structure of the Stapled Peptide Bound to Mdm2
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-P07:
1,8-DIETHYL-1,8-DIHYDRODIBENZO[3,4:7,8][1,2,3]TRIAZOLO[4',5':5,6]CYCLOOCTA[1,2-D][1,2,3]TRIAZOLE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • syhthetic construct (others)
KeywordsLIGASE / MDM2

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