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TitleKynurenine-3-Monooxygenase Inhibition Prevents Multiple Organ Failure in Rodent Models of Acute Pancreatitis.
Journal, issue, pagesNat. Med. (N. Y. ), Vol. 22, Page 202-, Year 2016
Publish dateNov 10, 2015 (structure data deposition date)
AuthorsMole, D.J. / Webster, S.P. / Uings, I. / Zheng, X. / Binnie, M. / Wilson, K. / Hutchinson, J.P. / Mirguet, O. / Walker, A. / Beaufils, B. ...Mole, D.J. / Webster, S.P. / Uings, I. / Zheng, X. / Binnie, M. / Wilson, K. / Hutchinson, J.P. / Mirguet, O. / Walker, A. / Beaufils, B. / Ancellin, N. / Trottet, L. / Beneton, V. / Mowat, C.G. / Wilkinson, M. / Rowland, P. / Haslam, C. / Mcbride, A. / Homer, N.Z. / Baily, J.E. / Sharp, M.G. / Garden, O.J. / Hughes, J. / Howie, S.E. / Holmes, D.S. / Liddle, J. / Iredale, J.P.
External linksNat. Med. (N. Y. ) / PubMed:26752518
MethodsX-ray diffraction
Resolution3.19 Å
Structure data

PDB-5fn0:
Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180
Method: X-RAY DIFFRACTION / Resolution: 3.19 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-JHY:
3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID

ChemComp-HOH:
WATER

Source
  • pseudomonas fluorescens (bacteria)
KeywordsOXIDOREDUCTASE / KMO

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