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Title | Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 1041-1051, Year 2016 |
Publish date | Dec 9, 2015 (structure data deposition date) |
![]() | Luo, G. / Chen, L. / Burton, C.R. / Xiao, H. / Sivaprakasam, P. / Krause, C.M. / Cao, Y. / Liu, N. / Lippy, J. / Clarke, W.J. ...Luo, G. / Chen, L. / Burton, C.R. / Xiao, H. / Sivaprakasam, P. / Krause, C.M. / Cao, Y. / Liu, N. / Lippy, J. / Clarke, W.J. / Snow, K. / Raybon, J. / Arora, V. / Pokross, M. / Kish, K. / Lewis, H.A. / Langley, D.R. / Macor, J.E. / Dubowchik, G.M. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.51 - 2.525 Å |
Structure data | ![]() PDB-5f94: ![]() PDB-5f95: |
Chemicals | ![]() ChemComp-3UO: ![]() ChemComp-HOH: ![]() ChemComp-3UP: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / GSK3b / TRANSFERASE-TRANSFERASE INHIBITOR complex |