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Structure paper

TitleThe crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA.
Journal, issue, pagesChem. Commun. (Camb. ), Vol. 52, Page 2354-2357, Year 2016
Publish dateJul 29, 2014 (structure data deposition date)
AuthorsKondo, J. / Nomura, Y. / Kitahara, Y. / Obika, S. / Torigoe, H.
External linksChem. Commun. (Camb. ) / PubMed:26731288
MethodsX-ray diffraction
Resolution1.5 - 1.9 Å
Structure data

PDB-4u6k:
Crystal structure of DNA/RNA duplex containing 2'-4'-BNA-NC
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-4u6l:
Crystal structure of DNA/RNA duplex obtained in the presence of [Co(NH3)6]Cl3 and SrCl2
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4u6m:
Crystal structure of DNA/RNA duplex obtained in the presence of Spermine
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-NCO:
COBALT HEXAMMINE(III)

ChemComp-HOH:
WATER

ChemComp-SR:
STRONTIUM ION

Source
  • synthetic construct (others)
KeywordsDNA/RNA / DNA/RNA duplex / antisense / Bridged Nucleic Acid / DNA-RNA complex / DNA/RNA hybrid duplex

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