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-Structure paper
Title | Subtle structural changes in the Asp251Gly/Gln307His P450 BM3 mutant responsible for new activity toward diclofenac, tolbutamide and ibuprofen. |
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Journal, issue, pages | Arch. Biochem. Biophys., Vol. 602, Page 106-115, Year 2016 |
Publish date | Sep 25, 2015 (structure data deposition date) |
Authors | Di Nardo, G. / Dell'Angelo, V. / Catucci, G. / Sadeghi, S.J. / Gilardi, G. |
External links | Arch. Biochem. Biophys. / PubMed:26718083 |
Methods | X-ray diffraction |
Resolution | 1.967 - 2.4 Å |
Structure data | PDB-5dyp: PDB-5dyz: |
Chemicals | ChemComp-HEM: ChemComp-HOH: ChemComp-140: |
Source |
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Keywords | OXIDOREDUCTASE / cytochrome P450 / random mutagenesis / drug metabolism / substrate |