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Structure paper

TitleThe first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches-toward anti-sense therapy against TREDs.
Journal, issue, pagesNucleic Acids Res., Vol. 44, Page 1937-1943, Year 2016
Publish dateNov 6, 2015 (structure data deposition date)
AuthorsKiliszek, A. / Banaszak, K. / Dauter, Z. / Rypniewski, W.
External linksNucleic Acids Res. / PubMed:26717983
MethodsX-ray diffraction
Resolution1.06 - 1.15 Å
Structure data

PDB-5eme:
Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC)
Method: X-RAY DIFFRACTION / Resolution: 1.15 Å

PDB-5emf:
Crystal structure of RNA r(GCUGCUGC) with antisense PNA p(GCAGCAGC)
Method: X-RAY DIFFRACTION / Resolution: 1.14 Å

PDB-5emg:
Crystal structures of PNA p(GCTGCTGC)2 duplex containing T-T mismatches
Method: X-RAY DIFFRACTION / Resolution: 1.06 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsRNA / CAG repeats / RNA/PNA / PNA antisense oligomer / poly-Q dieseases / CUG repeats / RNA/PNA duplex / antisense PNA / myotonic dystrophy type 1 / BIOSYNTHETIC PROTEIN / PNA-PNA duplex / TREDs / T-T mismatches

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