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Structure paper

TitleDistal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page 326-331, Year 2016
Publish dateJul 1, 2015 (structure data deposition date)
AuthorsHudson, W.H. / Kossmann, B.R. / de Vera, I.M. / Chuo, S.W. / Weikum, E.R. / Eick, G.N. / Thornton, J.W. / Ivanov, I.N. / Kojetin, D.J. / Ortlund, E.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:26715749
MethodsX-ray diffraction
Resolution1.997 - 2.405 Å
Structure data

PDB-5cbx:
AncGR DNA Binding Domain - (+)GRE Complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5cby:
AncGR2 DNA Binding Domain - (+)GRE Complex
Method: X-RAY DIFFRACTION / Resolution: 1.997 Å

PDB-5cbz:
AncMR DNA Binding Domain - (+)GRE Complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-5cc0:
AncSR2 - TSLP nGRE complex
Method: X-RAY DIFFRACTION / Resolution: 2.405 Å

PDB-5cc1:
S425G Glucocorticoid receptor DNA binding domain - (+)GRE complex
Method: X-RAY DIFFRACTION / Resolution: 2.302 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • unclassified (unknown)
  • synthetic construct (others)
  • unidentified (others)
  • homo sapiens (human)
Keywordsdna binding protein/dna / DNA binding protein / dna binding protein-dna complex / DNA binding proteins

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