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Structure paper

TitleSpiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.
Journal, issue, pagesAcs Chem. Biol., Vol. 11, Page 1001-1011, Year 2016
Publish dateJul 16, 2015 (structure data deposition date)
AuthorsMorgen, M. / Jost, C. / Malz, M. / Janowski, R. / Niessing, D. / Klein, C.D. / Gunkel, N. / Miller, A.K.
External linksAcs Chem. Biol. / PubMed:26686773
MethodsX-ray diffraction
Resolution1.49 - 1.75 Å
Structure data

PDB-5cls:
Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31a
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-5d6e:
Structure of human methionine aminopeptidase 2 with covalent spiroepoxytriazole inhibitor (-)-31b
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

PDB-5d6f:
Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31b
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-CO:
Unknown entry

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-52T:
(4R,7R)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate

ChemComp-CIT:
CITRIC ACID

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-94A:
(4R,7S)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate

ChemComp-TBU:
TERTIARY-BUTYL ALCOHOL

ChemComp-57R:
(4S,7R)-7-hydroxy-1-(4-methoxybenzyl)-7-methyl-4,5,6,7-tetrahydro-1H-benzotriazol-4-yl propan-2-ylcarbamate

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
KeywordsHYDROLASE / MetAP2 / methionine aminopeptidase-2 / inhibitor / spiroepoxytriazole / Methionine aminopeptidase 2 / Spiroepoxytriazoles

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