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-Structure paper
Title | The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains. |
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Journal, issue, pages | Medchemcomm, Vol. 4, Page 140-144, Year 2013 |
Publish date | Aug 21, 2012 (structure data deposition date) |
![]() | Hay, D. / Fedorov, O. / Filippakopoulos, P. / Martin, S. / Philpott, M. / Picaud, S. / Hewings, D.S. / Uttakar, S. / Heightman, T.D. / Conway, S.J. ...Hay, D. / Fedorov, O. / Filippakopoulos, P. / Martin, S. / Philpott, M. / Picaud, S. / Hewings, D.S. / Uttakar, S. / Heightman, T.D. / Conway, S.J. / Knapp, S. / Brennan, P.E. |
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Methods | X-ray diffraction |
Resolution | 1.6 Å |
Structure data | ![]() PDB-4gpj: |
Chemicals | ![]() ChemComp-0Q1: ![]() ChemComp-EDO: ![]() ChemComp-NA: ![]() ChemComp-HOH: |
Source |
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![]() | PROTEIN BINDING/INHIBITOR / BROMODOMAIN / CAP / HUNK1 / MCAP / MITOTIC CHROMOSOME ASSOCIATED PROTEIN / STRUCTURAL GENOMICS CONSORTIUM / SGC / CELL CYCLE / PROTEIN BINDING-INHIBITOR COMPLEX |