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-Structure paper
| Title | Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability. |
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| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 26, Page 575-579, Year 2016 |
| Publish date | Dec 8, 2014 (structure data deposition date) |
 Authors | Young, W.B. / Barbosa, J. / Blomgren, P. / Bremer, M.C. / Crawford, J.J. / Dambach, D. / Eigenbrot, C. / Gallion, S. / Johnson, A.R. / Kropf, J.E. ...Young, W.B. / Barbosa, J. / Blomgren, P. / Bremer, M.C. / Crawford, J.J. / Dambach, D. / Eigenbrot, C. / Gallion, S. / Johnson, A.R. / Kropf, J.E. / Lee, S.H. / Liu, L. / Lubach, J.W. / Macaluso, J. / Maciejewski, P. / Mitchell, S.A. / Ortwine, D.F. / Di Paolo, J. / Reif, K. / Scheerens, H. / Schmitt, A. / Wang, X. / Wong, H. / Xiong, J.M. / Xu, J. / Yu, C. / Zhao, Z. / Currie, K.S. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:26675441 |
| Methods | X-ray diffraction |
| Resolution | 1.356 Å |
| Structure data |  PDB-4rx5: |
| Chemicals |  ChemComp-SO4:  ChemComp-GOL:  ChemComp-PG0:  ChemComp-3YO:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE / protein kinase / phosphotransfer catalyst |
homo sapiens (human)