タイトル | Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules |
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ジャーナル・号・ページ | Mol. Pharmacol., Vol. 89, Page 233-242, Year 2016 |
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掲載日 | 2015年4月26日 (構造データの登録日) |
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著者 | Wang, Y. / Benz, F.W. / Wu, Y. / Wang, Q. / Chen, Y. / Chen, X. / Li, H. / Zhang, Y. / Zhang, R. / Yang, J. |
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リンク | Mol. Pharmacol. / PubMed:26660762 |
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手法 | X線回折 |
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解像度 | 2.5 - 2.55 Å |
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構造データ | PDB-4zhq: Crystal structure of Tubulin-Stathmin-TTL-MMAE Complex 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-4zi7: CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-HTI286 COMPLEX 手法: X-RAY DIFFRACTION / 解像度: 2.51 Å PDB-4zol: Crystal Structure of Tubulin-Stathmin-TTL-Tubulysin M Complex 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-5bmv: CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-Vinblastine COMPLEX 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-4Q5: N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide / モノメチルアウリスタチンE / 抗腫瘍剤*YM
ChemComp-4SL: N,beta,beta-trimethyl-L-phenylalanyl-N-[(3S,4Z)-5-carboxy-2-methylhex-4-en-3-yl]-N,3-dimethyl-L-valinamide
ChemComp-55Q: (2R,4R)-4-{[(2-{(1R,3R)-1-(acetyloxy)-4-methyl-3-[methyl(N-{[(2S)-1-methylpiperidin-2-yl]carbonyl}-D-isoleucyl)amino]pentyl}-1,3-thiazol-4-yl)carbonyl]amino}-2-methyl-5-phenylpentanoic acid
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由来 | - rattus norvegicus (ドブネズミ)
- gallus gallus (ニワトリ)
- sus scrofa (ブタ)
- bos taurus (ウシ)
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キーワード | STRUCTURAL PROTEIN/INHIBITOR / STRUCTURAL PROTEIN-INHIBITOR Complex / STRUCTURAL PROTEIN / Complex |
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