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Structure paper

TitleDecoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.
Journal, issue, pagesPlos One, Vol. 10, Page e0144061-e0144061, Year 2015
Publish dateOct 22, 2014 (structure data deposition date)
Authorsde Rosa, M. / Barbiroli, A. / Giorgetti, S. / Mangione, P.P. / Bolognesi, M. / Ricagno, S.
External linksPlos One / PubMed:26625273
MethodsX-ray diffraction
Resolution1.242 - 1.7 Å
Structure data

PDB-4rmq:
Crystal structure of the D59N Beta-2 Microglobulin mutant
Method: X-RAY DIFFRACTION / Resolution: 1.461 Å

PDB-4rmr:
Crystal structure of the D38N Beta-2 Microglobulin mutant
Method: X-RAY DIFFRACTION / Resolution: 1.529 Å

PDB-4rms:
Crystal structure of the D53N Beta-2 Microglobulin mutant
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4rmt:
Crystal structure of the D98N Beta-2 Microglobulin mutant
Method: X-RAY DIFFRACTION / Resolution: 1.242 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-PGE:
TRIETHYLENE GLYCOL

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / immunoglobin / beta-sandwitch / amyloidosis / pathologic mutation / genetic disease / MHC class I

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