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-Structure paper
Title | Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 26, Page 126-132, Year 2016 |
Publish date | Aug 29, 2015 (structure data deposition date) |
Authors | Raheem, I.T. / Schreier, J.D. / Fuerst, J. / Gantert, L. / Hostetler, E.D. / Huszar, S. / Joshi, A. / Kandebo, M. / Kim, S.H. / Li, J. ...Raheem, I.T. / Schreier, J.D. / Fuerst, J. / Gantert, L. / Hostetler, E.D. / Huszar, S. / Joshi, A. / Kandebo, M. / Kim, S.H. / Li, J. / Ma, B. / McGaughey, G. / Sharma, S. / Shipe, W.D. / Uslaner, J. / Vandeveer, G.H. / Yan, Y. / Renger, J.J. / Smith, S.M. / Coleman, P.J. / Cox, C.D. |
External links | Bioorg. Med. Chem. Lett. / PubMed:26602277 |
Methods | X-ray diffraction |
Resolution | 2 - 2.2 Å |
Structure data | PDB-5dh4: PDB-5dh5: |
Chemicals | ChemComp-ZN: ChemComp-MG: ChemComp-5AV: ChemComp-4PX: ChemComp-HOH: ChemComp-5AY: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |