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-Structure paper
タイトル | Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer. |
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ジャーナル・号・ページ | Proc Natl Acad Sci U S A, Vol. 112, Issue 46, Page 14266-14271, Year 2015 |
掲載日 | 2015年11月17日 |
著者 | Rui Wang / Rebecca L Stone / Jason T Kaelber / Ryan H Rochat / Alpa M Nick / K Vinod Vijayan / Vahid Afshar-Kharghan / Michael F Schmid / Jing-Fei Dong / Anil K Sood / Wah Chiu / |
PubMed 要旨 | Thrombocytosis and platelet hyperreactivity are known to be associated with malignancy; however, there have been no ultrastructure studies of platelets from patients with ovarian cancer. Here, we ...Thrombocytosis and platelet hyperreactivity are known to be associated with malignancy; however, there have been no ultrastructure studies of platelets from patients with ovarian cancer. Here, we used electron cryotomography (cryo-ET) to examine frozen-hydrated platelets from patients with invasive ovarian cancer (n = 12) and control subjects either with benign adnexal mass (n = 5) or free from disease (n = 6). Qualitative inspections of the tomograms indicate significant morphological differences between the cancer and control platelets, including disruption of the microtubule marginal band. Quantitative analysis of subcellular features in 120 platelet electron tomograms from these two groups showed statistically significant differences in mitochondria, as well as microtubules. These structural variations in the platelets from the patients with cancer may be correlated with the altered platelet functions associated with malignancy. Cryo-ET of platelets shows potential as a noninvasive biomarker technology for ovarian cancer and other platelet-related diseases. |
リンク | Proc Natl Acad Sci U S A / PubMed:26578771 / PubMed Central |
手法 | EM (トモグラフィー) |
構造データ | EMDB-6471: EMDB-6472: EMDB-6473: |
由来 |
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