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TitleTetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid.
Journal, issue, pagesJ. Biol. Chem., Vol. 291, Page 652-657, Year 2016
Publish dateMar 31, 2015 (structure data deposition date)
AuthorsHaruki, H. / Hovius, R. / Pedersen, M.G. / Johnsson, K.
External linksJ. Biol. Chem. / PubMed:26565027
MethodsX-ray diffraction
Resolution2.35 Å
Structure data

PDB-4z3k:
Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite xanthurenic acid
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-4KL:
Xanthuric acid / inhibitor, agonist*YM

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / sepiapterin-reductase / xanthurenic acid / inhibitor / tryptophan-metabolite

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